Surfaces and High-Density Molecular Arrays
Our research group combines combinatorial synthesis and high-throughput screening to explore molecular interactions and discover functional biomolecules. Our primary focus lies in studying peptides and their applications in understanding evolutionary processes, molecular recognition, and interactions with antibodies, proteins, RNA, polymers, and cells.
Helmholtz Association (HGF) Programm: NATURAL, ARTIFICIAL AND COGNITIVE INFORMATION PROCESSING / Topic: Molecular and Cellular Information.
The Nesterov-Mueller Research Group was founded through the ERC Starting Grant (COMBIPATTERNING, 2011–2016).
Research
Screening for Primordial RNA–Peptide Interactions Using High-Density Peptide Arrays
Highlights:
See for details: https://www.mdpi.com/1422-0067/23/7/3515 ; https://www.mdpi.com/2075-1729/11/9/975
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Resemblance-Ranking Peptide Library to Screen for Binders to Antibodies on a Peptidomic Scale
Highlights:
See for details: https://www.mdpi.com/1422-0067/23/7/3515
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Serological Number for Characterization of Circulating Antibodies
Highlights:
See for details: https://www.mdpi.com/1422-0067/20/3/604
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Selective Peptide Binders to the Perfluorinated Sulfonic Acid Ionomer Nafion
Highlights:
See for details: https://doi.org/10.1002/adfm.202214932
Scientific Chat: Peptides and fuel cells
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High-throughput screening for cell binding and repulsion peptides on multifunctionalized surfaces
Highlights:
See for details: https://www.nature.com/articles/s42003-024-06541-7
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Selected Publications:
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Sonnentag, S.J.; Jenne, F.; Orian-Rousseau, V.; Nesterov-Mueller, A. High-throughput screening for cell binding and repulsion peptides on multifunctionalized surfaces. Commun Biol 2024, 7, doi:ARTN 870 10.1038/s42003-024-06541-7
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Schmidt, D.; Gartner, P.; Berezkin, I.; Rudat, J.; Bilger, M.; Grünert, T.; Zimmerer, N.; Quarz, P.; Scharfer, P.; Brückel, J.; Jung, A. P.; Singh, P.; Pooja, P.; Meier, B.; Stahlberger, M.; Schabel, W.; Bräse, S.; Lanza, G.; Nesterov-Mueller, A. Selective Peptide Binders to the Perfluorinated Sulfonic Acid Ionomer Nafion. Adv Func Mater 2023, https://doi.org/10.1002/adfm.202214932
- Jenne, F.; Berezkin, I.; Tempel, F.; Schmidt, D.; Popov, R.; Nesterov-Mueller, A. Screening for Primordial RNA–Peptide Interactions Using High-Density Peptide Arrays. Life 2023, 13, 796. https://doi.org/10.3390/life13030796
- Jenne, F.; Biniaminov, S.; Biniaminov, N.; Marquardt, P.; von Bojničić-Kninski, C.; Popov, R.; Seckinger, A.; Hose, D.; Nesterov-Mueller, A. Resemblance-Ranking Peptide Library to Screen for Binders to Antibodies on a Peptidomic Scale. Int. J. Mol. Sci. 2022, 23, 3515.
- Babii, O.; Afonin, S.; Diel, C.; Huhn, M.; Dommermuth, J.; Schober, T.; Koniev, S.; Hrebonkin, A.; Nesterov-Mueller, A.; Komarov, I.V.; Ulrich A. Diarylethene-Based Photoswitchable Inhibitors of Serine Proteases. Angew Chem Int Edit 2021, 60, 21789-21794.
- Nesterov-Mueller, A.; Popov, R. The Combinatorial Fusion Cascade to Generate the Standard Genetic Code. Life 2021, 11, 975. https://doi.org/10.3390/life11090975
- Nesterov-Müller, A.; Popov, R. Die Botschaft von LUCA — der letzte universelle gemeinsame Vorfahre. Biospektrum 2020, 26, 488–489 8 (in German).
- Palermo, A.; Nesterov-Mueller, A. Serological Number for Characterization of Circulating Antibodies. Int J Mol Sci 2019, 20, doi:ARTN 604
- Held, F.E.; Guryev, A.A.; Frohlich, T.; Hampel, F.; Kahnt, A.; Hutterer, C.; Steingruber, M.; Bahsi, H.; von Bojnicic-Kninski, C.; Mattes, D.S.; Nesterov-Mueller, A.; Marschall, M.; Tsogoeva, S. Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions. Nat Commun 2017, 8, doi:ARTN 15071
- von Bojnicic-Kninski, C.; Popov, R.; Dorsam, E.; Loeffler, F.F.; Breitling, F.; Nesterov-Mueller, A. Combinatorial Particle Patterning. Adv Funct Mater 2017, 27, doi:ARTN 1703511
- Nesterov-Müller, A.: Erfolgreicher Grenzgang : Bunsen und Kirchhoff: Entdeckung der Spektralanalyse, Physik in unserer Zeit 2016, 47: 233–237, DOI: 10.1002/piuz.201601440 (in German).
- Popova, A.A.; Schillo, S.M.; Demir, K.; Ueda, E.; Nesterov-Mueller, A.; Levkin, P.A. Droplet-Array (DA) Sandwich Chip: A Versatile Platform for High-Throughput Cell Screening Based on Superhydrophobic-Superhydrophilic Micropatterning. Adv Mater 2015, 27, 5217-5222, doi:10.1002/adma.201502115.
- Maerkle, F.; Loeffler, F.F.; Schillo, S.; Foertsch, T.; Muenster, B.; Striffler, J.; Schirwitz, C.; Bischoff, F.R.; Breitling, F.; Nesterov-Mueller, A. High-Density Peptide Arrays with Combinatorial Laser Fusing. Adv Mater 2014, 26, 3730-3734, doi:10.1002/adma.201305759.